Increased brain white matter diffusivity in normal adult aging: Relationship to anisotropy and partial voluming
نویسندگان
چکیده
منابع مشابه
White matter hyperintensities and normal-appearing white matter integrity in the aging brain
White matter hyperintensities (WMH) of presumed vascular origin are a common finding in brain magnetic resonance imaging of older individuals and contribute to cognitive and functional decline. It is unknown how WMH form, although white matter degeneration is characterized pathologically by demyelination, axonal loss, and rarefaction, often attributed to ischemia. Changes within normal-appearin...
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BACKGROUND Gulf War exposures in 1990 and 1991 have caused 25% to 30% of deployed personnel to develop a syndrome of chronic fatigue, pain, hyperalgesia, cognitive and affective dysfunction. METHODS Gulf War veterans (n = 31) and sedentary veteran and civilian controls (n = 20) completed fMRI scans for diffusion tensor imaging. A combination of dolorimetry, subjective reports of pain and fati...
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BACKGROUND AND PURPOSE Hypertension is associated with the development of white matter lesions in older people. Diffusion tensor MRI can detect subtle, previsible white matter damage, but relationships between diffusion tensor MRI parameters and blood pressure (BP) remain unclear. We examined correlations among mean diffusivity (MD), fractional anisotropy and BP in 45 men aged 71 to 76 years. ...
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Individuals with 22q11.2 deletion syndrome (22q11.2DS) evince a 30% incidence of schizophrenia. We compared the white matter (WM) of 22q11.2DS patients without schizophrenia to a group of matched healthy controls using Tract-Based-Spatial-Statistics (TBSS). We found localized reduction of Fractional Anisotropy (FA) and Axial Diffusivity (AD; measure of axonal integrity) in WM underlying the lef...
متن کاملThe brain subcortical white matter and aging: A quantitative fractional anisotropy analysis
To study the integrity of hemispheric subcortical white matter by comparing normal young and elderly subjects using quantitative fractional anisotropy (DTI-FA). Methods Subjects of two different age groups (young=12, elderly=12) were included. MR - GE Signa Horizon - 1.5T scans were performed. Cases with Fazekas scores =3 were assessed on FLAIR sequence. Standard parameters for DTI-FA were us...
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ژورنال
عنوان ژورنال: Magnetic Resonance in Medicine
سال: 2003
ISSN: 0740-3194,1522-2594
DOI: 10.1002/mrm.10452